HEPATOCYTE GROWTH-FACTOR (HGF) MEDIATES THE SUSTAINED FORMATION OF 1,2-DIACYLGLYCEROL VIA PHOSPHATIDYLCHOLINE PHOSPHOLIPASE-C IN CULTURED RAT HEPATOCYTES

被引：56

作者：

OSADA, S

NAKASHIMA, S

SAJI, S

NAKAMURA, T

NOZAWA, Y

机构：

[1] GIFU UNIV,SCH MED,DEPT BIOCHEM,TSUKASAMACHI 40,GIFU 500,JAPAN

[2] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN

[3] GIFU UNIV,SCH MED,DEPT SURG 2,GIFU 500,JAPAN

来源：

FEBS LETTERS | 1992年 / 297卷 / 03期

关键词：

HEPATOCYTE GROWTH FACTOR (HGF); SUSTAINED DG FORMATION; PHOSPHATIDYLCHOLINE-PHOSPHOLIPASE-C; CA2+ OSCILLATION;

D O I：

10.1016/0014-5793(92)80554-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The addition of hepatocyte growth factor (HGF) to rat hepatocytes in primary culture resulted in the formation of inositol 1,4,5-trisphophate (Ins(1,4,5)P3) and 1,2-diacylglycerol (DG) by a phosphoinositide-specific phospholipase C (PI-PLC). DG showed a biphasic increase; the first phase, corresponding with the peak of Ins(1,4,5)P3 and a second larger and prolonged phase. The HGF stimulates the phosphatidylcholine (PC)-derived prolonged DG formation by a phospholipase C pathway (PC-PLC) but not by a phospholipase D pathway. HGF also was found to elicit [Ca2+] oscillations which may be associated with the prolonged DG production from PC via the PC-PLC phospholipase C pathway.

引用

页码：271 / 274

页数：4

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