APPLICATION OF 2D H-1-NMR SPECTROSCOPY TO THE STUDY OF THE BRAIN, SPINAL-CORD, AND SCIATIC-NERVE

被引：4

作者：

BELOEIL, JC

GILLET, B

FEDELI, O

BERENGER, G

LOMBARDI, V

MARZULLO, F

SCOZZAFAVA, A

机构：

[1] INST ONCOL,DIPARTIMENTO ANATIMIA PATOL,BARI,ITALY

[2] UNIV FLORENCE,DIPARTIMENTO CHIM,I-50121 FLORENCE,ITALY

来源：

MOLECULAR AND CHEMICAL NEUROPATHOLOGY | 1993年 / 19卷 / 1-2期

关键词：

SPECTROSCOPY; 2D NMR; INVIVO NMR; H-1-NMR; COSY; BRAIN; SPINAL CORD; SCIATIC NERVE; METABOLISM; FATTY ACIDS;

D O I：

10.1007/BF03160164

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Homonuclear H-1 2D NMR spectroscopy (COSY experiments at 400 and 600 MHz) were used to study the rat brain in vivo and the rabbit spinal cord and sciatic nerve in vitro. The following metabolites were identified: lactate, alanine, threonine, GABA, glutamine/glutamate, N-acetyl aspartate, aspartate, taurine, inositol derivatives, choline derivatives, and glucose. The sciatic nerve spectra showed characteristic COSY graphs of saturated and unsaturated fatty acids, and linoleic and linolenic type structures were identified.

引用

页码：1 / 13

页数：13

共 23 条

[1] 2D COSY H-1-NMR - A NEW TOOL FOR STUDYING INSITU BRAIN METABOLISM IN THE LIVING ANIMAL [J].