TARGET-CELLS MODULATE DOPAMINE TRANSPORTER GENE-EXPRESSION DURING BRAIN-DEVELOPMENT

被引：38

作者：

PERRONECAPANO, C ^{[1
]}

TINO, A ^{[1
]}

DIPORZIO, U ^{[1
]}

机构：

[1] UNIV NAPLES, DEPT GEN & ENVIRONM PHYSIOL, I-80134 NAPLES, ITALY

来源：

NEUROREPORT | 1994年 / 5卷 / 09期

关键词：

DOPAMINE TRANSPORTER; DOPAMINE UPTAKE; NIGRO-STRIATAL PATHWAY; SYNAPTIC VESICLE MONOAMINE TRANSPORTER; TYROSINE HYDROXYLASE; REVERSE TRANSCRIPTION PCR; NEURONAL PRIMARY CULTURES;

D O I：

10.1097/00001756-199405000-00031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE have analysed the expression of the dopamine transporter (DAT) gene and compared it with that of tyrosine hydroxylase, neuronal GABA transporter and synaptic vesicle monoamine transporter genes during pre- and post-natal development of rat mesencephalic dopaminergic (DA) neurones. Our results show that DAT transcripts are not detectable until embryonic day (E) 15, whilst those of the other genes analysed are already present at E12. In vitro, the level of DAT gene transcription in mesencephalic E13 DA neurones is increased in coculture with target striatal cells. Thus striatal targets cells regulate, at the transcriptional level, a key step of dopaminergic neurotransmission during DA neurone development.

引用

页码：1145 / 1148

页数：4

共 18 条

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