STIMULATION OF GLUCONEOGENESIS BY SOMATOSTATIN IN RAT-KIDNEY CORTEX SLICES

被引：12

作者：

LUPIANEZ, JA

DILEEPAN, KN

WAGLE, SR

机构：

[1] Department of Pharmacology Indiana University School of Medicine Indianapolis

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)90691-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of somatostatin on gluconeogenesis was studied in kidney cortex slices. Addition of somatostatin (2 μg) stimulated gluconeogenesis from lactate, pyruvate and glutamine by 42%, 50% and 68% respectively. Stimulation of glucose synthesis from lactate by somatostatin was found to be linear with time and dose dependent between 0.1 and 20 μg. Somatostatin-stimulated gluconeogenesis was inhibited by phentolamine (10 μM) but not by propranolol (10 μM) suggesting that somatostatin action is mediated by α-adrenergic stimuli. © 1979.

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页码：735 / 742

页数：8

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