ACTIVATED PROTEIN-C - ANTITHROMBOTIC PROPERTIES AND INFLUENCE ON FIBRINOLYSIS IN AN ANIMAL-MODEL

被引：10

作者：

ROMISCH, J

DIEHL, KH

REINER, G

PAQUES, EP

机构：

[1] J. Römisch, K-H. Diehl, G. Reiner, E-P. Pâques, Research Laboratories of Behringwerke AG, P.O. Box 11 40

来源：

FIBRINOLYSIS | 1991年 / 5卷 / 03期

关键词：

ACTIVATED PROTEIN-C; THROMBOSIS MODEL; HALF-LIFE; ANTITHROMBOTIC EFFECT; PROFIBRINOLYTIC EFFECT;

D O I：

10.1016/0268-9499(91)90023-W

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The in vivo antithrombotic and profibrinolytic properties of human plasma protein C were investigated in a metallic coil induced thrombus model in the rat. Protein C, purified immunoadsorption, was activated by thrombin and thereafter administered to the animals. Half-life of activated protein C (APC) revealed to be 15-16 min for the antigen, but only 7-8 min for the anticoagulant activity. Thrombus formation was reduced by APC in a dose-dependent statistically significant manner. A profibrinolytic effect of APC was observed when administered in combination with human tissue plasminogen activator. APC alone caused a reduction of thrombus weight. However, both effects were statistically not significant.

引用

页码：191 / 196

页数：6

共 25 条

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