INTRACELLULAR SIGNALING BY 14-HYDROXY-4,14-RETRO-RETINOL

被引：168

作者：

BUCK, J ^{[1
]}

DERGUINI, F ^{[1
]}

LEVI, E ^{[1
]}

NAKANISHI, K ^{[1
]}

HAMMERLING, U ^{[1
]}

机构：

[1] COLUMBIA UNIV,DEPT CHEM,NEW YORK,NY 10027

来源：

SCIENCE | 1991年 / 254卷 / 5038期

关键词：

D O I：

10.1126/science.1749937

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In mammals, retinol is the precursor for retinoids, which affect various aspects of morphogenesis and development. However, B lymphocytes, although retinol-dependent, do not use retinoic acid as mediator. Retinol is metabolized by B lymphocytes and other cell lines to optically active 14-hydroxy-4,14-retro-retinol; it is this compound that mediates the growth control. Thus another second messenger molecule, in addition to retinoic acid and retinal, is derived from retinol.

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页码：1654 / 1656

页数：3

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