PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE .1. PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITY

被引：69

作者：

OMURA, S

VANDERPYL, D

INOKOSHI, J

TAKAHASHI, Y

TAKESHIMA, H

机构：

[1] Research Center for Biological Function, The Kitasato Institute, Tokyo, 108, Shirokane 5-9-1, Minato-ku

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 02期

关键词：

D O I：

10.7164/antibiotics.46.222

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pepticinnamins A, B, C, D, E and F, a family of farnesyl-protein transferase (FPT) inhibitors were isolated from the fermentation broth of Streptomyces sp. OH-4652. These inhibitors were purified from whole broth by extraction with chloroform, followed by silica gel column chromatography, Sephadex LH-20 chromatography and reverse phase HPLC. Among these, pepticinnamin C showed the most potent inhibition (IC50 approximately 100 nm).

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页码：222 / 228

页数：7

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