A COMMENT ON THE ABSENCE OF CALCIUM REGULATION OF HUMAN THIOREDOXIN REDUCTASE

被引：9

作者：

OBLONG, JE ^{[1
]}

POWIS, G ^{[1
]}

机构：

[1] ARIZONA CANC CTR,1515 N CAMPBELL AVE,TUCSON,AZ 85715

来源：

FEBS LETTERS | 1993年 / 334卷 / 01期

关键词：

FLAVOENZYME; HUMAN; CALCIUM; REDOX;

D O I：

10.1016/0014-5793(93)81667-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been previously suggested that human thioredoxin reductase activity is regulated by calcium. However, the activity of a purified form of human placental thioredoxin reductase was found to not be affected by mM concentrations of calcium, well above intra- and extracellular physiological levels. Furthermore, the suggestion that an E-F hand is present in Escherichia coli thioredoxin reductase is strongly contested. These current results suggest that human thioredoxin reductase is not regulated by calcium.

引用

页码：1 / 2

页数：2

共 18 条

[1]

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[2]

[Anonymous], 1999, INTRO PROTEIN STRUCT

[3]

Cantor CR, 1980, BIOPHYS CHEM

[4] A GENETIC TOOL USED TO IDENTIFY THIOREDOXIN AS A MEDIATOR OF A GROWTH INHIBITORY SIGNAL [J].