THE EXPRESSION OF THE ABNORMAL HUMAN RED-CELL ANION TRANSPORTER FROM SOUTH-EAST ASIAN OVALOCYTES (BAND-3 SAO) IN XENOPUS-OOCYTES

被引：34

作者：

GROVES, JD ^{[1
]}

RING, SM ^{[1
]}

SCHOFIELD, AE ^{[1
]}

TANNER, MJA ^{[1
]}

机构：

[1] UNIV BRISTOL,SCH MED SCI,DEPT BIOCHEM,BRISTOL BS8 1TD,AVON,ENGLAND

来源：

FEBS LETTERS | 1993年 / 330卷 / 02期

基金：

英国惠康基金;

关键词：

HEREDITARY OVALOCYTOSIS; BAND-3; GLYCOPHORIN-A; ANION TRANSPORTER; XENOPUS OOCYTE;

D O I：

10.1016/0014-5793(93)80270-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

South-East Asian ovalocytosis (SAO) is caused by the heterozygous presence of a variant form of the human erythrocyte anion transporter (band 3; AE1). The expression of band 3 SAO has been studied in Xenopus oocytes. Band 3 SAO is not functional as an anion transporter but is inserted stably into the plasma membrane of oocytes. Band 3 SAO translocation to the cell surface does not require co-expression of normal band 3. Co-expression of glycophorin A (GPA) increases the rate of translocation of band 3 SAO to the oocyte membrane but is not essential for this process. We suggest that the increased tendency of band 3 SAO to form oligomers may facilitate its translocation to the cell surface.

引用

页码：186 / 190

页数：5

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