NEW INHIBITORS OF MELANOGENESIS, OH-3984 K1 AND K2 .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL CHARACTERISTICS

被引：23

作者：

KOMIYAMA, K

TAKAMATSU, S

TAKAHASHI, Y

SHINOSE, M

HAYASHI, M

TANAKA, H

IWAI, Y

OMURA, S

机构：

[1] KITASATO UNIV,KITASATO INST,5-9-1 SHIROKANE,MINATO KU,TOKYO 108,JAPAN

[2] KITASATO UNIV,SCH PHARMACEUT SCI,TOKYO 108,JAPAN

[3] KAO CORP,BIOL SCI LABS,HAGA,TOCHIGI 32134,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 10期

关键词：

D O I：

10.7164/antibiotics.46.1520

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Melanogenesis inhibitors, OH-3984 K1 and K2 were isolated from fermentation broth of Streptomyces sp. OH-3984. OH-3984 K1 and K2 inhibited the melanogenesis of B16 melanoma cells at concentrations of 7.5 and 3.8 mug/ml, respectively, whereas inhibition of tyrosinase activity has not been observed. The microbial metabolites showed no antimicrobiological activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1,000 mug/ml.

引用

页码：1520 / 1525

页数：6

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