SYNTHESIS AND ANTITUMOR-ACTIVITY OF 6-METHYL DERIVATIVES OF FLAVONE-8-ACETIC ACID (FAA)

被引：6

作者：

AITKEN, RA ^{[1
]}

BIBBY, MC ^{[1
]}

DOUBLE, JA ^{[1
]}

PHILLIPS, RM ^{[1
]}

SHARMA, SK ^{[1
]}

机构：

[1] UNIV BRADFORD,CLIN ONCOL UNIT,BRADFORD BD7 1DP,W YORKSHIRE,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 19期

关键词：

D O I：

10.1016/0960-894X(94)85031-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A range of 16 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.

引用

页码：2313 / 2316

页数：4

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