CHOLECYSTOKININ IN BRAINS OF OBESE AND NON-OBESE MICE

被引：129

作者：

STRAUS, E ^{[1
]}

YALOW, RS ^{[1
]}

机构：

[1] CUNY,MT SINAI SCH MED,NEW YORK,NY 10029

来源：

SCIENCE | 1979年 / 203卷 / 4375期

关键词：

D O I：

10.1126/science.758680

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Extracts of the cerebral cortex of genetically obese (ob/ob) mice with hyperphagia contain 0.05±0.02 microgram (mean ± standard error) of cholecystokinin octapeptide equivalent per gram of wet weight compared to 0.15±0.01 microgram per gram for their nonobese littermates and 0.20±0.01 microgram per gram for normal LAF1 mice. These findings are suggestive of a causal relation between the diminished brain immunoreactive cholecystokinin content and the unrestrained appetite of the obese mice. Copyright © 1978 AAAS.

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页码：68 / 69

页数：2

相关论文

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