NEW SYNTHESIS OF 2-AMINO-6-ALKOXYPYRAZINES FROM N-NITROSOBIS(CYANOMETHYL)AMINE AND ALKOXIDES

被引：9

作者：

VOHRA, SK

HARRINGTON, GW

ZACHARIAS, DE

SWERN, D

机构：

[1] TEMPLE UNIV,DEPT CHEM,PHILADELPHIA,PA 19122

[2] TEMPLE UNIV,FELS RES INST,PHILADELPHIA,PA 19122

[3] INST CANC RES,PHILADELPHIA,PA 19111

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 07期

关键词：

D O I：

10.1021/jo01321a021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of N-nitrosobis(cyanomethyl)amine with sodium alkoxides gives good yields of 2-amino-6-alkoxypyrazines in one step. Products were tentatively identified initially by spectral (1H and 13C NMR, UV, MS), polarographic, and elemental analytical methods. 2-Amino-6-methoxypyrazine was unequivocally identified by singlecrystal X-ray examination. © 1979, American Chemical Society. All rights reserved.

引用

页码：1128 / 1130

页数：3

共 16 条

[1]

ACHESON RM, 1976, INTRO CHEM HETEROCYC, P407

[2]

BERNSTEIN HJ, 1974, 2ND ANN AEC SCI COMP, P148

[3] UNUSUALLY MILD AND FACILE BASIC HYDROLYSIS OF N-NITROSO-2-(METHYLAMINO)ACETONITRILE [J].