HIGH-AFFINITY BINDING OF [H-3]MUSCIMOL TO SUBCELLULAR PARTICLES OF A NEURON-ENRICHED CULTURE OF EMBRYONIC RAT-BRAIN

被引：31

作者：

DEFEUDIS, FV ^{[1
]}

OSSOLA, L ^{[1
]}

SCHMITT, G ^{[1
]}

MANDEL, P ^{[1
]}

机构：

[1] FAC MED STRASBOURG,INST CHIM BIOL,F-67085 STRASBOURG,FRANCE

来源：

NEUROSCIENCE LETTERS | 1979年 / 14卷 / 2-3期

关键词：

D O I：

10.1016/0304-3940(79)96147-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

High-affinity, Na+-independent binding of [3H]muscimol (KB {reversed tilde equals} 1.6 × 10-8 M; Bmax {reversed tilde equals} 0.14 nmol/g pellet) occurred to a frozen-thawed particulate fraction of 74-h-old neurone-enriched cultures prepared from the cerebra of 12-13-day-old rat embryos. This finding provides evidence that GABA-receptors exist on cultured neurones which contain only a few synaptic connections. © 1979.

引用

页码：195 / 199

页数：5

共 18 条

[1] MUSCIMOL BINDING IN RAT-BRAIN - ASSOCIATION WITH SYNAPTIC GABA RECEPTORS
BEAUMONT, K
CHILTON, WS
YAMAMURA, HI
ENNA, SJ
[J]. BRAIN RESEARCH, 1978, 148 (01) : 153 - 162
[2] BOOHER J, 1972, Neurobiology (Copenhagen), V2, P97
[3] NEUROTRANSMITTER METABOLISM IN CELL-CULTURE
BREAKEFIELD, XO
GILLER, EL
[J]. BIOCHEMICAL PHARMACOLOGY, 1976, 25 (21) : 2337 - 2342
[4] ULTRASTRUCTURAL LOCALIZATION OF GAMMA-AMINOBUTYRIC ACID RECEPTORS IN MAMMALIAN CENTRAL NERVOUS-SYSTEM BY MEANS OF [H-3] MUSCIMOL BINDING
CHANPALAY, V
PALAY, SL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (06) : 2977 - 2980
[5] GAMMA-AMINOBUTYRIC ACID RECEPTORS VISUALIZED IN SPINAL-CORD CULTURES BY [MUSCIMOL-H-3 AUTORADIOGRAPHY
CHANPALAY, V
YONEZAWA, T
YOSHIDA, S
PALAY, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (12) : 6281 - 6284
[6] PREFERENTIAL BINDING OF GAMMA-AMINOBUTYRIC ACID AND GLYCINE TO SYNAPTOSOME-ENRICHED FRACTIONS OF RAT CEREBRAL-CORTEX AND SPINAL-CORD
DEFEUDIS, FV
[J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1974, 52 (02) : 138 - 147
[7] DEFEUDIS FV, J NEUROCHEM
[8] DEFEUDIS FV, GEN PHARMACOL
[9] ACTION AND UPTAKE OF NEUROTRANSMITTERS IN CNS TISSUE-CULTURE
HOSLI, L
HOSLI, E
[J]. REVIEWS OF PHYSIOLOGY BIOCHEMISTRY AND PHARMACOLOGY, 1978, 81 : 135 - 188
[10] NEUROPHARMACOLOGY OF AMINO-ACID INHIBITORY TRANSMITTERS
JOHNSTON, GAR
[J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1978, 18 : 269 - 289

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