PROPIOLALDEHYDE, A PARGYLINE METABOLITE THAT IRREVERSIBLY INHIBITS ALDEHYDE DEHYDROGENASE - ISOLATION FROM A HEPATIC MICROSOMAL SYSTEM

被引：53

作者：

SHIROTA, FN

DEMASTER, EG

NAGASAWA, HT

机构：

[1] VET ADM HOSP,MED CTR,MED RES LABS,MINNEAPOLIS,MN 55417

[2] UNIV MINNESOTA,DEPT MED CHEM,MINNEAPOLIS,MN 55417

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 05期

关键词：

D O I：

10.1021/jm00191a001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The characteristic “disulfiram syndrome” associated with certain alcohol-drug interactions1 has been attributed in part to acetaldehydemia and subsequent release of biogenic amines.2 The ability of pargyline (N-methyl-N-propargylbenzylamine, 1) to cause marked elevations. © 1979, American Chemical Society. All rights reserved.

引用

页码：463 / 464

页数：2

共 16 条

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[9] ENZYMIC OXIDATION ALPHA TO ACETYLENIC GROUP IN METABOLISM OF N-(5-PYRROLIDINOPENT-3-YNYL)-SUCCINIMIDE (BL14) INVITRO [J].

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