INTERACTION BETWEEN CORTICOSTEROID BINDING GLOBULIN AND ACTIVATED LEUKOCYTES INVITRO

被引：27

作者：

HAMMOND, GL

SMITH, CL

UNDERHILL, CM

NGUYEN, VTT

机构：

[1] UNIV WESTERN ONTARIO,MRC,NEONATAL HLTH & DEV GRP,LONDON N6A 3K7,ONTARIO,CANADA

[2] UNIV WESTERN ONTARIO,DEPT OBSTET & GYNECOL,LONDON N6A 3K7,ONTARIO,CANADA

[3] UNIV WESTERN ONTARIO,DEPT ONCOL,LONDON N6A 3K7,ONTARIO,CANADA

[4] UNIV WESTERN ONTARIO,DEPT BIOCHEM,LONDON N6A 3K7,ONTARIO,CANADA

[5] ALLELIX BIOPHARMACEUT INC,MISSISSAUGA,ONTARIO,CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0006-291X(05)80189-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction between human corticosteroid binding globulin and activated leukocytes is restricted to the granulocyte population, and is characterized by specific proteolytic cleavage of corticosteroid binding globulin which markedly reduces its steroid binding activity. A direct. interaction between corticosteroid binding globulin and the activated cells appears to enhance this event, and does not involve cellular internalization of corticosteroid binding globulin or its proteolytic degradation products, which resemble those obtained after incubation of corticosteroid binding globulin with neutrophil elastase. These data suggest that corticosteroid binding globulin interacts with elastase on the surface of activated neutrophils, and may promote glucocorticoid delivery to these cells during inflammation. © 1990 Academic Press, Inc.

引用

页码：172 / 177

页数：6

共 13 条

[1]

Fahey J, 1981, ADV INFLAMMAT RES, V2, P21

[2] STIMULATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE SUPEROXIDE ANION RADICAL PRODUCTION BY TUMOR PROMOTERS [J].