STEREOSELECTIVE SYNTHESIS OF A HYDROXYETHYLENE DIPEPTIDE ISOSTERE

被引：31

作者：

DIEDERICH, AM ^{[1
]}

RYCKMAN, DM ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM,PHARMACEUT,DEPT SYNTHET CHEM,709 SWEDELAND RD,KING OF PRUSSIA,PA 19406

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(00)73701-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of a hydroxyethylene dipeptide isostere for Phe-Gly, (4S, 5S)-4-hydroxy-5-amino-6-phenylhexanoic acid, is described. The use of dibenzyl protecting groups on ketoamine 5 accounts for the selectivity on reduction. Also, the dibenzyl group plays a role in directing the introduction of a third chiral center.

引用

页码：6169 / 6172

页数：4

共 7 条

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