POLYAMINES IN RAT-BRAIN EXTRACELLULAR-SPACE AFTER ISCHEMIA

被引:12
作者
GILAD, GM
CASERO, RA
BUSTO, R
GLOBUS, MYT
机构
[1] ST ELIZABETH HOSP,NIMH,CTR NEUROSURG,NEUROPSYCHIAT BRANCH,WASHINGTON,DC 20032
[2] JOHNS HOPKINS UNIV,SCH MED,JOHNS HOPKINS ONCOL CTR,BALTIMORE,MD 21231
[3] UNIV MIAMI,SCH CHEM,DEPT NEUROL D4-5,CEREBRAL VASC DIS RES CTR,MIAMI,FL 33101
关键词
POLYAMINES; EXTRACELLULAR PUTRESCINE; SPERMIDINE AND SPERMINE; ISCHEMIA; TRANSIENT GLOBAL ISCHEMIA; BRAIN; DORSOLATERAL REGION OF THE RAT CORPUS STRIATUM; MICRODIALYSIS; EXTRACELLULAR FLUID COLLECTION BY MICRODIALYSIS PROBE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC); POLYAMINE MEASUREMENTS BY HPLC;
D O I
10.1007/BF03160020
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This article reports measurements of extracellular polyamines in rat brain. Microdialysis probes were implanted in the striatum and microperfusion samples were collected before, during, and after transient (20 min) global ischemia. Polyamine levels in microperfusates were measured by reverse-phase high-performance liquid chromatography after precolumn derivatization. No significant changes in extracellular polyamines were detected for up to 3 h following ischemia. We conclude that extracellular levels of polyamines (1) are comparable to the low levels in other extracellular compartments, and (2) do not change during the initial period of reperfusion, the period most critical for neuron survival after ischemia.
引用
收藏
页码:27 / 33
页数:7
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