PEPTIDOMIMETIC SYNTHESIS - UTILIZATION OF N-ACYLIMINIUM ION CYCLIZATION CHEMISTRY IN THE GENERATION OF 7,6-FUSED AND 7,5-FUSED BICYCLIC LACTAMS

被引：64

作者：

ROBL, JA

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute P. O., Princeton, NJ 08450-4000

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 03期

关键词：

D O I：

10.1016/0040-4039(94)85062-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the stereoselective generation of 7,6- and 7,5-fused bicyclic lactams of type 1 has been developed. The key step involves intramolecular N-acyliminium ion cyclization of N-acyl enamine 2 to generate the core bicyclic framework. Lactams of type 1 may be viewed as conformationally restricted mimics of alanyl proline.

引用

页码：393 / 396

页数：4

共 20 条

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