AGING LENGTHENS CIRCADIAN PERIOD FOR WHEEL-RUNNING ACTIVITY IN C57BL MICE

被引:50
作者
POSSIDENTE, B
MCELDOWNEY, S
PABON, A
机构
[1] Department of Biology, Skidmore College Saratoga Springs
关键词
CIRCADIAN PERIOD; AGING; MICE; WHEEL-RUNNING; PHOTOPERIOD;
D O I
10.1016/0031-9384(94)00298-J
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Previous reports of age effects on circadian period in rodents show a slight shortening of period with age, with the exception of house mice (Mus domesticus) where a number of studies report mixed results. The present study consists of three comparisons of circadian period for wheel-running activity in young vs. older C57BL inbred mice following entrainment to 16:8 LD, 12:12 LD and 8:16 LD photoperiods. The free-running circadian period (tau(DD)) for wheel-running activity was significantly longer in older mice following entrainment to all three photoperiods. These results support a model of heterogeneous effects of aging on circadian period among different rodent species, and suggest that the lengthening of circadian period with age in house mice is not a function of age-dependent differences in after-effects imposed by prior entrainment.
引用
收藏
页码:575 / 579
页数:5
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