MISSING ANTIPROLIFERATIVE EFFECT OF FISH-OIL ON RECTAL EPITHELIUM IN HEALTHY-VOLUNTEERS CONSUMING A HIGH-FAT DIET - POTENTIAL ROLE OF THE N-3/N-6 FATTY-ACID RATIO

被引：52

作者：

BARTRAM, HP ^{[1
]}

GOSTNER, A ^{[1
]}

REDDY, BS ^{[1
]}

RAO, CV ^{[1
]}

SCHEPPACH, W ^{[1
]}

DUSEL, G ^{[1
]}

RICHTER, A ^{[1
]}

RICHTER, F ^{[1
]}

KASPER, H ^{[1
]}

机构：

[1] AMER HLTH FDN,VALHALLA,NY 10595

来源：

EUROPEAN JOURNAL OF CANCER PREVENTION | 1995年 / 4卷 / 03期

关键词：

ANTICARCINOGENESIS; ANTIPROLIFERATION; COLORECTUM; FISH OIL; N-3 FATTY ACID; N-6 FATTY ACID;

D O I：

10.1097/00008469-199506000-00004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several studies have indicated dietary fish oil (FO) as a protective agent in colon carcinogenesis. Rectal cell proliferation as an intermediate biomarker of cancer risk was shown to be reduced by dietary FO in patients with adenomatous polyps and healthy subjects consuming a low-fat diet. Because the synthesis of prostaglandins (PG) which seem to be involved in this process is dependent on the ratio of n-3:n-6 fatty acids in the diet, the present study was designed to investigate whether this FO effect is also detectable in volunteers eating a high-fat diet (50% of energy) with a low n-3:n-6 ratio of 0.25. Twelve healthy volunteers received in addition to a controlled basal diet either FO (4.4 g n-3 fatty acids/day) or corn oil supplements (double-blind, crossover) for two 4-week periods. No significant differences between the two study periods were found for rectal cell proliferation as assessed by bromodeoxyuridine immunohistochemistry and ornithine decarboxylase activity, as well as for mucosal PGE(2) release and mucosal membrane fatty acid composition. The results emphasize the importance of dietary n-3:n-6 ratio in determining the effects of FO on rectal cell proliferation.

引用

页码：231 / 237

页数：7

共 34 条

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