CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS - MORPHOLOGICAL SEQUENCE OF MYELIN DEGRADATION

被引:26
作者
LASSMANN, H
WISNIEWSKI, HM
机构
[1] New York State Institute for Basic Research in Mental Retardation, Staten Island
关键词
D O I
10.1016/0006-8993(79)91036-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Myelin degradation in chronic relapsing experimental allergic encephalomyelitis was studied using light microscopic histochemistry and electron microscopy. In the earliest stages, a large number of myelin stripping macrophages were found. The Luxol fast blue positive degradation products were then gradually transformed into PAS positive material. No sudanophilic stage of myelin degradation was found in this model. In electron microscopy, the Luxol fast blue positive material was identified as uniformly layered lipid inclusions with a periodicity of 4.0-4.5 nm. During further digestion, this material was transformed into polymorph structured material, consisting of lamellar leaflets with a diameter of 7-10 nm, curved cylindrical profiles and granular osmiophilic material. © 1979.
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页码:357 / 368
页数:12
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