1,25-DIHYDROXYVITAMIN-D3 AND AGENTS THAT INCREASE INTRACELLULAR ADENOSINE-3',5'-MONOPHOSPHATE SYNERGISTICALLY INHIBIT THE MITOGENIC STIMULATION OF HUMAN-LYMPHOCYTES

被引：15

作者：

RAVID, A

KOREN, R

NARINSKY, R

ROTEM, C

NOVOGRODSKY, A

LIBERMAN, UA

机构：

[1] BEILINSON MED CTR, METAB DIS UNIT, IL-49100 PETACH TIQWA, ISRAEL

[2] TEL AVIV UNIV, SACKLER SCH MED, TEL AVIV, ISRAEL

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1990年 / 70卷 / 06期

关键词：

D O I：

10.1210/jcem-70-6-1687

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

1, 25-Dihydroxyvitamin D3 [1, 25-(OH)2D3], like the immune response modulators prostaglandin E2 (PGE2) and histamine, inhibits mitogen-induced proliferation of human peripheral blood mononuclear cells. 1, 25-(OH)2D3 acts synergistically with PGE2 and histamine to inhibit lymphocyte mitogenesis. This is apparent at a wide concentration range of 1, 25-(OH)2D3 (3 × 10−11−10−8 mol/L). Cholera toxin, forskolin, and isobutylmethylxanthine, which like PGE2 and histamine increase intracellular concentrations of cAMP, also act synergistically with 1, 25-(OH)2D3 in this system. Culture of mitogenstimulated adherent cell-depleted mononuclear cells with PGE2 increases the number of high affinity binding sites for 1, 25-(OH)2D3. This finding may account for the synergistic interaction between the two agents. © 1990 by The Endocrine Society.

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页码：1687 / 1692

页数：6

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