CONTRAINDICATION TO THE USE OF OCULAR PHENYLEPHRINE IN IDIOPATHIC ORTHOSTATIC HYPOTENSION

被引：27

作者：

ROBERTSON, D

机构：

[1] Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 1979年 / 87卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0002-9394(79)90361-1

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We studied the effect of a topical ocular application of 2.5% phenylephrine ophthalmic solution in patients with idiopathic orthostatic hypotension and in normal subjects. The normal subjects had no pressor effect to the drug. However, the patients with idiopathic orthostatic hypotension, had a marked pressor response. The maximal pressor response in the four patients averaged 44 27 mm Hg. The usual 10% phenylephrine used in practice could have delivered a fourfold greater amount of drug, and presumably would have led to dangerously high blood pressure responses. © 1979.

引用

页码：819 / 822

页数：4

共 19 条

[1] A COMPARATIVE STUDY OF MYDRIATIC AND CYCLOPLEGIC AGENTS - IN HUMAN SUBJECTS WITHOUT EYE DISEASE [J].