ENHANCED VASOCONSTRICTOR EFFECT OF ENDOTHELIN IN CEREBRAL-ARTERIES FROM RATS WITH SUBARACHNOID HEMORRHAGE

被引：54

作者：

ALAFACI, C

JANSEN, I

ARBAB, MAR

SHIOKAWA, Y

SVENDGAARD, NA

EDVINSSON, L

机构：

[1] UNIV LUND HOSP,DEPT INTERNAL MED,S-22185 LUND,SWEDEN

[2] UNIV LUND HOSP,DEPT EXPTL RES,S-22185 LUND,SWEDEN

[3] UNIV LUND HOSP,DEPT NEUROSURG,S-22185 LUND,SWEDEN

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1990年 / 138卷 / 03期

关键词：

Cerebral artery; Endothelin; Rat; Subarachnoid haemorrhage;

D O I：

10.1111/j.1748-1716.1990.tb08852.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline-injected controls. Endothelin elicited concentration-dependent contractions of rat basilar artery segments. The endothelin-induced contractions were much stronger in the SAH compared to control animals, which suggests a role in the pathophysiology of cerebral vasospasm.

引用

页码：317 / 319

页数：3

共 6 条

[1] SUBARACHNOID HEMORRHAGE IN THE RAT - ANGIOGRAPHY AND FLUORESCENCE MICROSCOPY OF THE MAJOR CEREBRAL-ARTERIES
DELGADO, TJ
BRISMAR, J
SVENDGAARD, NA
[J]. STROKE, 1985, 16 (04) : 595 - 602
[2] THERAPEUTIC TRIAL OF INTRAVENOUS NIMODIPINE IN PATIENTS WITH ESTABLISHED CEREBRAL VASOSPASM AFTER RUPTURE OF INTRACRANIAL ANEURYSMS
JAN, M
BUCHHEIT, F
TREMOULET, M
[J]. NEUROSURGERY, 1988, 23 (02) : 154 - 157
[3] MECHANISMS OF ACTION OF ENDOTHELIN ON ISOLATED FELINE CEREBRAL-ARTERIES - INVITRO PHARMACOLOGY AND ELECTROPHYSIOLOGY
JANSEN, I
FALLGREN, B
EDVINSSON, L
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1989, 9 (06) : 743 - 747
[4] ALTERATIONS IN ENDOTHELIUM-DEPENDENT RESPONSIVENESS OF THE CANINE BASILAR ARTERY AFTER SUBARACHNOID HEMORRHAGE
KIM, P
SUNDT, TM
VANHOUTTE, PM
[J]. JOURNAL OF NEUROSURGERY, 1988, 69 (02) : 239 - 246
[5] TOMOBE Y, 1988, EUR J PHARMACOL, V106, P47
[6] A NOVEL POTENT VASOCONSTRICTOR PEPTIDE PRODUCED BY VASCULAR ENDOTHELIAL-CELLS
YANAGISAWA, M
KURIHARA, H
KIMURA, S
TOMOBE, Y
KOBAYASHI, M
MITSUI, Y
YAZAKI, Y
GOTO, K
MASAKI, T
[J]. NATURE, 1988, 332 (6163) : 411 - 415

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