VARIATIONS IN THE RESPONSE OF 5 STRAINS OF MICE TO LEISHMANIA-MEXICANA

被引：82

作者：

PEREZ, H ^{[1
]}

LABRADOR, F ^{[1
]}

TORREALBA, JW ^{[1
]}

机构：

[1] UNIV CARABOBO,VALENCIA,VENEZUELA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1979年 / 9卷 / 01期

关键词：

agglutinating antibodies; AKR; Balb/c; C57BL/6; DBA/2; delayed type hypersensitivity response; hybrid; Leishmania mexicana; NMRI;

D O I：

10.1016/0020-7519(79)90062-6

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Five strains of mice were studied in their ability to support Leishmania mexicana infection. Four strains, AKR, C57BL/6, DBA/2 and NMRI, were relatively resistant to cutaneous leishmaniasis. These strains developed delayed type hypersensitivity responses to leishmanial antigens and produced agglutinating antibodies. On the other hand Balb/c mice, highly susceptible to infection, failed to develop delayed type hypersensitivity responses and showed an impaired production of antibodies. Hybrids produced by mating C57BL/6 males and Balb/c females were no more susceptible than C57BL/6 mice, suggesting that resistance is inherited as a dominant character. © 1979.

引用

页码：27 / 32

页数：6

共 17 条

[1]

BRADLEY DJ, 1972, T ROY SOC TROP MED H, V66, P527

[2] GENETIC-CONTROL OF NATURAL RESISTANCE TO LEISHMANIA-DONOVANI [J].