NEUROENDOCRINE EVIDENCE FOR DECREASED FUNCTION OF ALPHA(2)-ADRENERGIC RECEPTOR AFTER ELECTROCONVULSIVE-THERAPY

被引：8

作者：

BALLDIN, J

BERGGREN, U

LINDSTEDT, G

MODIGH, K

机构：

[1] GOTHENBURG UNIV,DEPT PSYCHIAT & NEUROCHEM,S-41124 GOTHENBURG,SWEDEN

[2] GOTHENBURG UNIV,DEPT CLIN CHEM,S-41124 GOTHENBURG,SWEDEN

来源：

PSYCHIATRY RESEARCH | 1992年 / 41卷 / 03期

关键词：

AFFECTIVE DISORDER; GROWTH HORMONE; CLONIDINE; BLOOD PRESSURE;

D O I：

10.1016/0165-1781(92)90007-P

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Growth hormone (GH) and hypotensive responses to clonidine (150-mu-g, i.v.) were investigated before and after electroconvulsive therapy (ECF) in 16 depressed patients. Because of high baseline serum GH concentrations, results from only 10 patients could be evaluated. The level of GH secretion induced by clonidine was significantly reduced after ECT, but the hypotensive responses to clonidine remained unchanged. The results indicate downward regulation of the sensitivity of alpha-2-adrenergic receptors in the hypothalamus after ECT.

引用

收藏

页码：257 / 265

页数：9

相关论文

共 25 条

[1] BLUNTED RESPONSE OF GROWTH-HORMONE TO CLONIDINE AND APOMORPHINE IN ENDOGENOUS-DEPRESSION [J].

ANSSEAU, M ;

VONFRENCKELL, R ;

CERFONTAINE, JL ;

PAPART, P ;

FRANCK, G ;

TIMSITBERTHIER, M ;

GEENEN, V ;

LEGROS, JJ .

BRITISH JOURNAL OF PSYCHIATRY, 1988, 153 :65-71

[2] INTERNATIONAL RELIABILITY AND COMMUNICABILITY OF A RATING SCALE FOR DEPRESSION [J].

ASBERG, M ;

KRAGHSOR.P ;

MINDHAM, RHS ;

TUCK, JR .

PSYCHOLOGICAL MEDICINE, 1973, 3 (04) :458-465

[3] NEUROENDOCRINE EVIDENCE FOR INCREASED RESPONSIVENESS OF DOPAMINE-RECEPTORS IN HUMANS FOLLOWING ELECTROCONVULSIVE-THERAPY [J].

BALLDIN, J ;

GRANERUS, AK ;

LINDSTEDT, G ;

MODIGH, K ;

WALINDER, J .

PSYCHOPHARMACOLOGY, 1982, 76 (04) :371-376

[4]

CHARNEY DS, 1982, ARCH GEN PSYCHIAT, V39, P290

[5] THE GH RESPONSE TO CLONIDINE IN ENDOGENOUS AS COMPARED WITH REACTIVE DEPRESSION [J].

CHECKLEY, SA ;

GLASS, IB ;

THOMPSON, C ;

CORN, T ;

ROBINSON, P .

PSYCHOLOGICAL MEDICINE, 1984, 14 (04) :773-777

[6] GROWTH-HORMONE AND OTHER RESPONSES TO CLONIDINE IN PATIENTS WITH ENDOGENOUS-DEPRESSION [J].

CHECKLEY, SA ;

SLADE, AP ;

SHUR, E .

BRITISH JOURNAL OF PSYCHIATRY, 1981, 138 (JAN) :51-55

[7] RESPONSES OF GROWTH-HORMONE TO DESIPRAMINE IN ENDOGENOUS AND NONENDOGENOUS DEPRESSION [J].

DINAN, TG ;

BARRY, S .

BRITISH JOURNAL OF PSYCHIATRY, 1990, 156 :680-684

[8]

DOLAN RJ, 1986, AM J PSYCHIAT, V143, P772

[9] UP-REGULATION AND DOWN-REGULATION OF CENTRAL POSTSYNAPTIC ALPHA-2-RECEPTORS REFLECTED IN THE GROWTH-HORMONE RESPONSE TO CLONIDINE IN RESERPINE-PRETREATED RATS [J].

ERIKSSON, E ;

EDEN, S ;

MODIGH, K .

PSYCHOPHARMACOLOGY, 1982, 77 (04) :327-331

[10]

GREEN AR, 1986, CIBA F S, V123, P234