MULTIPARAMETER OPTIMIZATIONS IN MICELLAR LIQUID-CHROMATOGRAPHY USING THE ITERATIVE REGRESSION OPTIMIZATION STRATEGY

被引：40

作者：

STRASTERS, JK ^{[1
]}

KIM, ST ^{[1
]}

KHALEDI, MG ^{[1
]}

机构：

[1] N CAROLINA STATE UNIV,DEPT CHEM,POB 8204,RALEIGH,NC 27695

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 586卷 / 02期

关键词：

D O I：

10.1016/0021-9673(91)85126-Z

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An extension of the iterative regression optimization strategy to multi-parameter optimizations is described and applied to the separation of ionic compounds (amino acids and peptides) by means of micellar liquid chromatography. The parameters examined are the concentration of surfactant, the concentration of 2-propanol and pH. Fairly regular (linear, weakly curved) retention behaviour of the compounds as a function of the parameters results in an efficient optimization using a relatively small number of initial experiments.

引用

页码：221 / 232

页数：12

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