PH-LACTATE DISSOCIATION IN NEONATAL ANOXIA - PROTON AND P-31 NMR SPECTROSCOPIC STUDIES IN RAT PUPS

被引：12

作者：

HIDA, K

SUZUKI, N

KWEE, IL

NAKADA, T

机构：

[1] DEPT VET AFFAIRS MED CTR,NEUROCHEM RES LAB,150 MUIR RD,MARTINEZ,CA 94553

[2] UNIV CALIF DAVIS,DEPT NEUROL,DAVIS,CA 95616

来源：

MAGNETIC RESONANCE IN MEDICINE | 1991年 / 22卷 / 01期

关键词：

D O I：

10.1002/mrm.1910220113

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The pH controlling capability of brain of 1‐day‐old rat pups was investigated using proton (1H) and phosphorus‐31 (31P) nuclear magnetic resonance (NMR) in vivo spectroscopy. Despite significantly high levels of lactate accumulation, brain of 1‐day‐old pups showed remarkable capability of maintaining brain pH virtually unchanged throughout 22 min of anoxia. The study supports the concepts that lactic acidosis is one of the important factors determining the outcome of cerebral anoxia and that the significantly higher pH controlling capability of immature brain plays a key role in the higher resistance toward anoxia. © 1991 Academic Press, Inc. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company

引用

页码：128 / 132

页数：5

共 17 条

[1] INTRACELLULAR PH, LACTATE, AND ENERGY-METABOLISM IN NEONATAL BRAIN DURING PARTIAL ISCHEMIA MEASURED INVIVO BY P-31 AND H-1 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY [J].