COMPLEX KARYOTYPE WITH PH1 CHROMOSOME IN MYELODYSPLASIA - CYTOGENETIC AND MOLECULAR STUDIES

被引：9

作者：

LARRIPA, I

GUTIERREZ, M

GIERE, I

ACEVEDO, S

BENGIO, R

SLAVUTSKY, I

机构：

[1] Sectión Citogenética, Academia Nacional de Medicina, Buenos Aires

[2] Departamento de Clinica Hematológical, Instituto de Investigaciones Hematológicas Mariano R. Castex Academia Nacional de Medicina, Buenos Aires

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 6卷 / 4-5期

关键词：

PHILADELPHIA CHROMOSOME; MYELODYSPLASIA; GENE REARRANGEMENTS; CANCER CYTOGENETICS;

D O I：

10.3109/10428199209053573

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report here a patient with Ph1-positive myelodysplasia with a complex karyotype. The patient presented with severe refractory anemia and ineffective erythropoiesis. In addition to t(9;22), chromosomes no. 1, 11, 12 and X also showed structural aberrations. Serial chromosome analyses revealed an increase of the Ph1-positive cell line along with the evolution of the disease (50% to 100% Southern blot analysis showed a breakpoint cluster region (bcr) rearrangement as described for chronic myeloid leukemia (CML). The disease evolved into an acute leukemia after 4 years without any clinical evidences of CML. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：401 / 406

页数：6

共 41 条

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