THYROTROPIN-RELEASING-HORMONE (TRH) ANALOGS SHOW ENHANCED CNS SELECTIVITY BECAUSE OF INCREASED BIOLOGICAL STABILITY

被引：32

作者：

METCALF, G

DETTMAR, PW

LYNN, AG

BREWSTER, D

HAVLER, ME

机构：

来源：

REGULATORY PEPTIDES | 1981年 / 2卷 / 05期

关键词：

D O I：

10.1016/0167-0115(81)90032-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：277 / 284

页数：8

共 16 条

[1] TRH DEGRADATION RATES VARY WIDELY BETWEEN DIFFERENT ANIMAL SPECIES [J].

BREWSTER, D ;

WALTHAM, K .

BIOCHEMICAL PHARMACOLOGY, 1981, 30 (06) :619-622

[2] AN ANALOG OF THYROTROPIN RELEASING HORMONE WITH IMPROVED BIOLOGICAL STABILITY BOTH INVITRO AND INVIVO [J].

BREWSTER, D ;

RANCE, MJ .

BIOCHEMICAL PHARMACOLOGY, 1980, 29 (19) :2619-2623

[3] METABOLISM AND PHARMACOKINETICS OF TRH AND AN ANALOG WITH ENHANCED NEURO-PHARMACOLOGICAL POTENCY [J].

BREWSTER, D ;

HUMPHREY, MJ ;

WAREING, MV .

NEUROPEPTIDES, 1981, 1 (03) :153-165

[4] MODIFICATION OF THE PROLINE RESIDUE OF TRH ENHANCES BIOLOGICAL-ACTIVITY AND INHIBITS DEGRADATION [J].

BREWSTER, D ;

DETTMAR, PW ;

LYNN, AG ;

METCALF, G ;

MORGAN, BA ;

RANCE, MJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1980, 66 (01) :65-71

[5] BIOLOGICAL EVALUATION OF A TRH ANALOG WITH A MODIFIED PROLINE RESIDUE [J].

DETTMAR, PW ;

FORTUNE, D ;

LYNN, AG ;

METCALF, G ;

MORGAN, BA .

NEUROPHARMACOLOGY, 1980, 19 (12) :1247-1248

[6] NEW TABLES FOR MULTIPLE COMPARISONS WITH CONTROL [J].

DUNNETT, CW .

BIOMETRICS, 1964, 20 (03) :482-&

[7]

FINNEY DJ, 1952, STATISTICAL METHOD B, P99

[8]

FRIDERICHS E, 1979, H-S Z PHYSIOL CHEM, V360, P1146

[9]

HORITA A, 1975, PSYCHOPHARMACOL COMM, V1, P403

[10]

METCALF G, 1981, LANCET, V1, P586

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