GRANULOMATOUS REACTION TO BRUCHS MEMBRANE IN AGE-RELATED MACULAR DEGENERATION

被引：128

作者：

DASTGHEIB, K

GREEN, WR

机构：

[1] JOHNS HOPKINS UNIV,WILMER OPHTHALMOL INST,EYE PATHOL LAB,BALTIMORE,MD 21287

[2] JOHNS HOPKINS MED INST,DEPT PATHOL,BALTIMORE,MD 21205

来源：

ARCHIVES OF OPHTHALMOLOGY | 1994年 / 112卷 / 06期

关键词：

D O I：

10.1001/archopht.1994.01090180111045

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

The histopathologic features of a granulomatous reaction in one eye of a patient with neovascular age-related macular degeneration are presented. Multiple multinucleated giant cells were found in intimate association with Bruch's membrane and at the margin of Bruch's membrane defects. Multinucleated giant cells appear to participate in the breakdown of Bruch's membrane and, together with diffuse disease of the retinal pigment epithelium and changes in the physicochemical properties of Bruch's membrane, may provide angiogenic stimulus for choroidal neovascularization in age-related macular degeneration.

引用

页码：813 / 818

页数：6

共 46 条

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GROWTH-REGULATION OF THE VASCULAR SYSTEM - EVIDENCE FOR A METABOLIC HYPOTHESIS [J].