PRODUCTION AND SECRETION OF PROTEINS BY STREPTOMYCETES

被引：86

作者：

GIBERT, M ^{[1
]}

MOROSOLI, R ^{[1
]}

SHARECK, F ^{[1
]}

KLUEPFEL, D ^{[1
]}

机构：

[1] UNIV QUEBEC, INST ARMAND FRAPPIER, CTR RECH MICROBIOL APPL, LAVAL, PQ H7N 4Z3, CANADA

来源：

CRITICAL REVIEWS IN BIOTECHNOLOGY | 1995年 / 15卷 / 01期

关键词：

STREPTOMYCES LIVIDANS; PROTEIN SECRETION; SIGNAL PEPTIDES; HETEROLOGOUS GENE EXPRESSION;

D O I：

10.3109/07388559509150530

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptomycetes produce a large number of extracellular enzymes as part of their saprophytic mode of life. Their ability to synthesize enzymes as products of their primary metabolism could lead to the production of many proteins of industrial importance. The development of high-yielding expression systems for both homologous and heterologous gene products is of considerable interest. In this article, we review the current knowledge on the various factors that affect the production and secretion of proteins by streptomycetes and try to evaluate the suitability of these bacteria for the large-scale production of proteins of industrial importance.

引用

页码：13 / 39

页数：27

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