SYNTHESIS OF 8-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINES

A general synthesis for the preparation of previously unreported 8-phenyl-l, 2, 3, 4-tetrahydroisoquinolines is described. he directing properties of aryloxazolines were used for an unambiguous route to appropriate 1, 2, 3-trisubstituted benzenes (2, 6-disubstituted aryloxazolines). Hydrolysis of the oxazolines produced 8-phenylisocoumarins, which were readily converted into the 8-phenylisoquinoline derivatives. © 1979, American Chemical Society. All rights reserved.