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ORNITHINE DECARBOXYLASE ACTIVITY AND POLYAMINE CONTENT IN ADENOCARCINOMAS OF HUMAN STOMACH AND LARGE-INTESTINE

被引：43
作者：
BERDINSKIKH, NK
IGNATENKO, NA
ZALETOK, SP
GANINA, KP
CHORNIY, VA
机构：
[1] RE KAVETSKY ONCOL PROBLEMS INST,DEPT TUMOR GROWTH GENET,KIEV,UKRAINE,USSR
[2] MINIST HLTH,KIEV ONCOL RES INST,DEPT ABDOMINAL,KIEV,UKRAINE,USSR
来源：
INTERNATIONAL JOURNAL OF CANCER | 1991年 / 47卷 / 04期
关键词：
D O I：
10.1002/ijc.2910470404
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ornithine decarboxylase (ODC) activity and differential polyamine composition have been studied in macroscopically normal mucosa, adjacent mucosa, and neoplastic tissue of 95 patients with adenocarcinomas of stomach and large intestine. In tumors, we found increased ODC activity and polyamine content as compared with surrounding mucosa. ODC activity in macroscopically normal tissue of patients with tumors of stomach and large intestine increased as the disease progressed. An inverse relationship was observed between ODC activity in adenocarcinomas and differentiation.
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页码：496 / 498
页数：3
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