IMMUNOLOGICAL STUDIES OF THE TOXIC SITE IN AMMODYTOXIN-A

被引：24

作者：

CURINSERBEC, V

NOVAK, D

BABNIK, J

TURK, D

GUBENSEK, F

机构：

[1] J STEFAN INST, DEPT BIOCHEM, POB 100, YU-61111 LJUBLJANA, CROATIA

[2] RUDJER BOSKOVIC INST, DEPT EXPTL MED & BIOL, YU-41001 ZAGREB, CROATIA

[3] BORIS KIDRIC INST CHEM, YU-61115 LJUBLJANA, CROATIA

来源：

FEBS LETTERS | 1991年 / 280卷 / 01期

关键词：

PHOSPHOLIPASE-A2; NEUROTOXIN; TOXIC SITE; VIPERA-AMMODYTES; MONOCLONAL ANTIBODY;

D O I：

10.1016/0014-5793(91)80231-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two monoclonal antibodies against the native ammodytoxin A and four site-directed polyclonal antibodies against synthetic peptides derived from the primary structure of the toxin were prepared in order to estimate the localization of its toxic site. Some of the antibodies neutralized the lethal toxicity of the toxin, thus indicating an approximate position of the toxic or receptor binding site on the molecule that is different from those predicted by comparison with a number of known sequences.

引用

页码：175 / 178

页数：4

共 29 条

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