PREPARATION OF DIASTEREOMERIC URETHANE DERIVATIVES OF ATROPINE AND L-HYOSCYAMINE USING (-)-1-PHENYLETHYLISOCYANATE

被引：2

作者：

LANDEN, WO ^{[1
]}

CAINE, DS ^{[1
]}

机构：

[1] GEORGIA INST TECHNOL,SCH CHEM,ATLANTA,GA 30332

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 08期

基金：

英国医学研究理事会;

关键词：

Atropine—derivatives; urethane diastereomers; chemical synthesis; Diastereomers—atropine and l‐hyoscyamine urethane derivatives; Hyoscyamine—derivatives;

D O I：

10.1002/jps.2600680831

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Diastereomeric urethane derivatives of atropine (d,l‐hyoscyamine) and l‐hyoscyamine were prepared by reacting the alkaloids with (−)‐1‐phenylethylisocyanate. The derivatives, as the picrate ion‐pairs, were characterized by their melting points, optical rotations, elemental analyses, and IR, NMR, and UV‐visible spectra. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1039 / 1041

页数：3

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