CHRONIC NEUROLEPTIC ADMINISTRATION DECREASES EXTRACELLULAR GABA IN THE NUCLEUS-ACCUMBENS BUT NOT IN THE CAUDATE-PUTAMEN OF RATS

被引：17

作者：

SEE, RE ^{[1
]}

CHAPMAN, MA ^{[1
]}

KLITENICK, MA ^{[1
]}

机构：

[1] WASHINGTON STATE UNIV,DEPT VET & COMPARAT ANAT PHARMACOL & PHYSIOL,PULLMAN,WA 99164

来源：

BRAIN RESEARCH | 1992年 / 588卷 / 01期

关键词：

GAMMA-AMINOBUTYRIC ACID; HALOPERIDOL; FLUPHENAZINE; CAUDATE-PUTAMEN; NUCLEUS ACCUMBENS; MICRODIALYSIS;

D O I：

10.1016/0006-8993(92)91361-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The extracellular levels of gamma-aminobutyric acid (GABA) in the caudate-putamen and the nucleus accumbens of rats following administration of haloperidol decanoate, fluphenazine decanoate, OT vehicle for 8 months were assessed using intracranial microdialysis. Basal levels of extracellular GABA were significantly decreased in the nucleus accumbens of both neuroleptic-treated groups while levels of GABA in the caudate-putamen were not significantly different between groups. These results provide evidence for selective chronic neuroleptic-induced effects on in vivo GABA function in different terminal regions containing dopamine receptors.

引用

页码：177 / 180

页数：4

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