IN-VIVO VISUALIZATION OF MYELIN WATER IN BRAIN BY MAGNETIC-RESONANCE

被引：748

作者：

MACKAY, A ^{[1
]}

WHITTALL, K ^{[1
]}

ADLER, J ^{[1
]}

LI, D ^{[1
]}

PATY, D ^{[1
]}

GRAEB, D ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DIV NEUROL,VANCOUVER,BC,CANADA

来源：

MAGNETIC RESONANCE IN MEDICINE | 1994年 / 31卷 / 06期

关键词：

T-2; RELAXATION; MYELIN; BRAIN; MULTIPLE SCLEROSIS;

D O I：

10.1002/mrm.1910310614

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We exploit the intrinsic difference in magnetic resonance spin-spin relaxation time, T-2, between water associated with myelin sheaths and water in other central nervous system tissue in order to measure myelin water content within any region of an image or to generate indirectly a myelin map of the brain. In normal volunteers, myelin water maps give the expected myelin distribution. In multiple sclerosis patients, lesions exhibit different myelin water contents providing insight into the demyelination process unavailable from conventional magnetic resonance images. In vivo myelin measurement has important applications in the clinical management of multiple sclerosis and other white matter diseases.

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页码：673 / 677

页数：5

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