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INDUCTION OF OXYGEN-FREE RADICAL GENERATION IN HUMAN MONOCYTES BY LIPOPROTEIN(A)

被引：38
作者：
HANSEN, PR
KHARAZMI, A
JAUHIAINEN, M
EHNHOLM, C
机构：
[1] UNIV COPENHAGEN,RIGSHOSP,DEPT CLIN MICROBIOL,DK-2100 COPENHAGEN,DENMARK
[2] NATL PUBL HLTH INST,DEPT BIOCHEM,HELSINKI,FINLAND
来源：
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1994年 / 24卷 / 07期
关键词：
ATHEROSCLEROSIS; FREE RADICALS; LIPOPROTEIN(A); MONOCYTES-MACROPHAGES;
D O I：
10.1111/j.1365-2362.1994.tb02381.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The mechanism behind the association of elevated plasma lipoprotein(a) [Lp(a)l levels with atherosclerotic disease is unknown. In the present study, Lp(a) induced generation of oxygen free radicals by monocytes from selected healthy individuals in vitro. This observation may provide a link between Lp(a) and generation of oxidized LDL, which can promote multiple atherogenic cellular responses.
引用
收藏
页码：497 / 499
页数：3
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