DISPOSITION OF CARBAMAZEPINE AND PHENYTOIN IN PREGNANCY

被引：64

作者：

TOMSON, T ^{[1
]}

LINDBOM, U ^{[1
]}

EKQVIST, B ^{[1
]}

SUNDQVIST, A ^{[1
]}

机构：

[1] HUDDINGE UNIV HOSP,DEPT CLIN PHARMACOL,HUDDINGE,SWEDEN

来源：

EPILEPSIA | 1994年 / 35卷 / 01期

关键词：

EPILEPSY; PREGNANCY; ANTICONVULSANTS; CARBAMAZEPINE-10-11-EPOXIDE; PHENYTOIN; PHARMACOKINETICS; CLEARANCE;

D O I：

10.1111/j.1528-1157.1994.tb02922.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Free and total plasma concentrations of phenytoin (PHT) and carbamazepine (CBZ) and its active metabolite carbamazepine-10,11-epoxide (CBZ-E) were determined in a prospective study of 86 pregnant epileptic women. The pharmacokinetics of PHT and CBZ during the three trimesters were compared with kinetics at least 10 weeks postpartum. Plasma clearance and unbound CBZ clearance were slightly decreased during the last trimester. Total and free plasma CBZ-E concentrations did not change significantly during pregnancy. Plasma PHT clearance, on the other hand, increased from the first trimester. A less pronounced increase was observed for clearance of unbound PHT; the increase was statistically significant only during the third trimester.

引用

页码：131 / 135

页数：5

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