THE NMDA ANTAGONIST MK-801 BLOCKS LIGHT EFFECT ON MELATONIN RECEPTOR DENSITY IN RAT SUPRACHIASMATIC NUCLEI

被引：14

作者：

GAUER, F ^{[1
]}

MASSONPEVET, M ^{[1
]}

PEVET, P ^{[1
]}

机构：

[1] UNIV STRASBOURG 1,CNRS,URA 1332,F-67000 STRASBOURG,FRANCE

来源：

NEUROSCIENCE LETTERS | 1994年 / 171卷 / 1-2期

关键词：

MELATONIN RECEPTOR; SUPRACHIASMATIC NUCLEUS; LIGHT PULSE; MK-801; NMDA RECEPTOR; PINEALECTOMY; MELATONIN;

D O I：

10.1016/0304-3940(94)90595-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In pinealectomized rats, melatonin receptor density in the suprachiasmatic nuclei was recently shown to be strongly decreased during the dark period. Furthermore, a one-hour long light pulse is able to reverse this dark-induced decrease. We demonstrate here that this effect of a light-pulse during night time is blocked by prior application of the NMDA receptor antagonist MK-801. These results show that the light effect on melatonin receptor density in the SCN is mediated by activation of NMDA-type receptors.

引用

页码：24 / 26

页数：3

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