NUCLEOSIDES AND NUCLEOTIDES .128. (2'S)-2'-DEOXY-2'-C-METHYL-5-IODOURIDINE (SMIU) AS A NOVEL POTENT ANTI-HERPES VIRUS AGENT

被引：35

作者：

AWANO, H

SHUTO, S

BABA, M

KIRA, T

SHIGETA, S

MATSUDA, A

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

[2] FUKUSHIMA MED COLL,DEPT BACTERIOL,FUKUSHIMA 96012,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80146-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(2'S)-2'-deoxy-2'-C-methyl-5-halogenopyrimidine nucleosides were designed and synthesized as anti-herpes virus agents. Of these compounds, (2'S)-2'-deoxy-2'-C-methyl-5-iodouridine (SMIU, 9e) showed the greatest anti-HSV-l activity in vitro while showing no cytotoxicity. SMIU is a candidate drug for clinical treatment of herpes virus infection disease.

引用

页码：367 / 370

页数：4

共 18 条

[1] CYTO-TOXICITY OF 2'-FLUORO-5-IODO-1-BETA-D-ARABINOFURANOSYLCYTOSINE AND ITS RELATIONSHIP TO DEOXYCYTIDINE DEAMINASE
CHENG, YC
TAN, RS
RUTH, JL
DUTSCHMAN, G
[J]. BIOCHEMICAL PHARMACOLOGY, 1983, 32 (04) : 726 - 729
[2] CHOU TC, 1981, CANCER RES, V41, P3336
[3] DECLERCQ E, 1988, ANTIVIRAL DRUG DEV M
[4] HAYAKAWA H, 1987, CHEM PHARM BULL, V35, P2605
[5] KREIS W, 1983, BIOCHEM PHARMACOL, V31, P767
[6] LOPEZ C, 1980, ANTIMICROB AGENTS CH, V17, P303
[7] MACHIDA H, 1993, NUCLEOSIDES AND NUCLEOTIDES AS ANTITUMOR AND ANTIVIRAL AGENTS, P245
[8] MATSUDA A, 1987, CHEM PHARM BULL, V35, P3967
[9] NUCLEOSIDES AND NUCLEOTIDES .94. RADICAL DEOXYGENATION OF TERT-ALCOHOLS IN 1-(2-C-ALKYLPENTOFURANOSYL)PYRIMIDINES - SYNTHESIS OF (2'S)-2'-DEOXY-2'-C-METHYLCYTIDINE, AN ANTILEUKEMIC NUCLEOSIDE
MATSUDA, A
TAKENUKI, K
SASAKI, T
UEDA, T
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) : 234 - 239
[10] NUCLEOSIDES AND NUCLEOTIDES .95. IMPROVED SYNTHESIS OF 1-(2-AZIDO-2-DEOXY-BETA-D-ARABINOFURANOSYL)CYTOSINE (CYTARAZID) AND THYMINE - INHIBITORY SPECTRUM OF CYTARAZID ON THE GROWTH OF VARIOUS HUMAN TUMOR-CELLS INVITRO
MATSUDA, A
YASUOKA, J
SASAKI, T
UEDA, T
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (03) : 999 - 1002

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