ROLE OF PARAFOLLICULAR CELL OF THYROID GLAND IN PATHOGENESIS OF CONGENITAL OSTEOPETROSIS IN MICE

被引：40

作者：

MARKS, SC

WALKER, DG

机构：

[1] Department of Anatomy, The Johns Hopkins School of Medicine, Baltimore, Maryland

[2] Dental Research Department, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland

来源：

AMERICAN JOURNAL OF ANATOMY | 1969年 / 126卷 / 03期

关键词：

D O I：

10.1002/aja.1001260305

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Congenital osteopetrosis as manifested in the grey‐lethal, microphthalmic and osteosclerotic stocks of the house mouse is characterized by an increased rate of bone matrix formation, hyperplasia of the parafollicular cell population of the thyroid gland and hypocalcemia. Osteopetrotic mice were abnormally resistant to the tendencies of parathyroid extract to promote hypercalcemia and to depress osteogenesis. The results of this investigation suggest that the parafollicular cell is the source of an osteoblast‐stimulating factor and that an excess of this factor results in osteopetrosis. Copyright © 1969 Wiley‐Liss, Inc.

引用

页码：299 / &

共 24 条

[1]

BARNICOT NA, 1948, J ANAT, V82, P233

[2] Studies on the factors involved in bone absorption I The effect of subcutaneous transplantation of bones of the Grey Lethal house mouse into Normal hosts and of Normal bones into Grey Lethal hosts [J].