UTERINE EXPRESSION OF LEUKEMIA INHIBITORY FACTOR COINCIDES WITH THE ONSET OF BLASTOCYST IMPLANTATION

被引：481

作者：

BHATT, H ^{[1
]}

BRUNET, LJ ^{[1
]}

STEWART, CL ^{[1
]}

机构：

[1] ROCHE INST MOLEC BIOL,ROCHE RES CTR,DEPT CELL & DEV BIOL,NUTLEY,NJ 07110

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 24期

关键词：

MOUSE EMBRYO; UTERUS; ESTROGEN;

D O I：

10.1073/pnas.88.24.11408

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have analyzed the expression of the cytokine leukemia inhibitory factor (LIF) during embryogenesis and in tissues of neonatal and adult mice. The site of the most abundant LIF expression is the uterine endometrial glands, specifically on day 4 of pregnancy. Analysis of LIF expression in pseudopregnant mice and in females undergoing delayed implantation showed that it is under maternal control and that its expression coincides with blastocyst formation and always precedes implantation. These results suggest that a principal function of LIF in vivo may be to regulate the growth and to initiate implantation of blastocysts.

引用

页码：11408 / 11412

页数：5

共 33 条

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