PRIMARY CENTRAL WHITE-MATTER DEGENERATION IN OLD DOGS

被引：24

作者：

FERRER, I

PUMAROLA, M

RIVERA, R

ZUJAR, MJ

CRUZSANCHEZ, F

VIDAL, A

机构：

[1] UNIV AUTONOMA BARCELONA, FAC MED, NEUROL TISSUE BANK, BARCELONA, SPAIN

[2] UNIV AUTONOMA BARCELONA, SCH VET, DEPT PATHOL, BARCELONA, SPAIN

来源：

ACTA NEUROPATHOLOGICA | 1993年 / 86卷 / 02期

关键词：

AGING; WHITE MATTER; UBIQUITIN; GALACTOCEREBROSIDE;

D O I：

10.1007/BF00334884

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Degeneration of the central white matter is described in old dogs. The presence of ubiquitin-immunoreactive free granules and intracytoplasmic globules in glial cells and macrophages, together with galactocerebroside-immunoreactive precipitates and lipofuscin storage, point to the likelihood of a primary myelin degeneration with deposits of non-degraded ubiquitin-protein conjugates and complex galactolipids.

引用

收藏

页码：172 / 175

页数：4

相关论文

共 20 条

[1] UBIQUITIN IN CEREBRAL AMYLOID ANGIOPATHY [J].

CRUZSANCHEZ, FF ;

MARIN, C ;

ROSSI, ML ;

CARDOZO, A ;

FERRER, I ;

TOLOSA, E .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1992, 112 (1-2) :46-50

[2]

DICKSON DW, 1990, LAB INVEST, V63, P87

[3] ARTERIOLOSCLEROTIC LEUKOENCEPHALOPATHY IN THE ELDERLY AND ITS RELATION TO WHITE MATTER LESIONS IN BINSWANGERS DISEASE, MULTIINFARCT ENCEPHALOPATHY AND ALZHEIMERS-DISEASE [J].

FERRER, I ;

BELLA, R ;

SERRANO, MT ;

MARTI, E ;

GUIONNET, N .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1990, 98 (01) :37-50

[4] UBIQUITINATION [J].

FINLEY, D ;

CHAU, V .

ANNUAL REVIEW OF CELL BIOLOGY, 1991, 7 :25-69

[5]

GEORGE AE, 1986, AM J NEURORADIOL, V7, P567

[6] DIFFUSE WHITE-MATTER DISEASE IN THE GERIATRIC POPULATION - A CLINICAL, NEUROPATHOLOGICAL, AND CT STUDY [J].

GOTO, K ;

ISHII, N ;

FUKASAWA, H .

RADIOLOGY, 1981, 141 (03) :687-695

[7] LEUKOARAIOSIS [J].

HACHINSKI, VC ;

POTTER, P ;

MERSKEY, H .

ARCHIVES OF NEUROLOGY, 1987, 44 (01) :21-23

[8]

HATTORI H, 1992, ACTA NEUROPATHOL, V84, P437

[9] THE UBIQUITIN SYSTEM FOR PROTEIN-DEGRADATION [J].

HERSHKO, A ;

CIECHANOVER, A .

ANNUAL REVIEW OF BIOCHEMISTRY, 1992, 61 :761-807

[10] LEWY BODIES ARE UBIQUITINATED - A LIGHT AND ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMICAL STUDY [J].

KUZUHARA, S ;

MORI, H ;

IZUMIYAMA, N ;

YOSHIMURA, M ;

IHARA, Y .

ACTA NEUROPATHOLOGICA, 1988, 75 (04) :345-353