SELECTIVELY O-ACYLATED GLYCOSAMINOGLYCAN DERIVATIVES

被引：27

作者：

PETITOU, M ^{[1
]}

COUDERT, C ^{[1
]}

LEVEL, M ^{[1
]}

LORMEAU, JC ^{[1
]}

ZUBER, M ^{[1
]}

SIMENEL, C ^{[1
]}

FOURNIER, JP ^{[1
]}

CHOAY, J ^{[1
]}

机构：

[1] FAC PHARM PARIS,F-75005 PARIS,FRANCE

来源：

CARBOHYDRATE RESEARCH | 1992年 / 236卷

关键词：

D O I：

10.1016/0008-6215(92)85010-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycosaminoglycans, particularly heparin and heparin fragments, were specifically O-acetylated by use of tetrabutylammonium or tributylammonium salts of the anionic polysaccharides, carboxylic acid anhydrides, and 4-dimethylaminopyridine in an homogeneous way in N,N-dimethylformamide. The number of acyl chains introduced on the carbohydrate backbone was determined either after transesterification and quantitative analysis of the butyl esters thus obtained by GLC or by H-1 NMR spectroscopy.

引用

页码：107 / 119

页数：13

共 17 条

[1]

ANWER MK, 1981, TETRAHEDRON LETT, P4369

[2] AN ACETYL DERIVATIVE OF HEPARIN [J].