CHROMOSOME MAPPING OF SOA, A GENE INFLUENCING GUSTATORY SENSITIVITY TO SUCROSE OCTAACETATE IN MICE

Strain distribution patterns among recombinant inbred strains suggested that a locus influencing taste sensitivity to sucrose octaacetate was on chromosome 6. A location for Soa was established by linkage analysis of behavioral and electrophoretic data from outbred and congenic strains and from test-cross progeny. Haplotyping of 41 outbred CFW-Cr animals with a cDNA probe showed perfect cosegregation of Soa and Prp, a gene for salivary proline-rich proteins. Five of twelve B6.SW-Soa(a) StrainS were found to retain Ldr-1, lactate dehydrogenase regulator-1, on chromosome 6 as an allelic passenger from the SWR/J donor strain (source of the Soa(a) Taster allele). Centimorgan distance was estimated using the ABP/Le linkage-testing strain (non-Taster, Soa(b)) and the SWR/J strain (Taster, Soa(a)) in a testcross breeding system. The data are consistent with a position for the Soa locus on mouse chromosome 6, 62 cM from the centromere.