HEPATITIS-B AND HEPATITIS-D GENOMES IN HEPATITIS-B SURFACE-ANTIGEN NEGATIVE PATIENTS WITH CHRONIC HEPATITIS-C

被引：22

作者：

GONZALEZ, S ^{[1
]}

NAVAS, S ^{[1
]}

MADEJON, A ^{[1
]}

BARTOLOME, J ^{[1
]}

CASTILLO, I ^{[1
]}

MORALEDA, G ^{[1
]}

MARTIN, J ^{[1
]}

MARRIOTT, E ^{[1
]}

HERRERO, M ^{[1
]}

CARRENO, V ^{[1
]}

机构：

[1] FDN JIMENEZ DIAZ,HEPATOL UNIT,E-28040 MADRID,SPAIN

来源：

JOURNAL OF MEDICAL VIROLOGY | 1995年 / 45卷 / 02期

关键词：

PCR; HBV; HDV; HCV; LIVER;

D O I：

10.1002/jmv.1890450210

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis B and hepatitis D viral genomes were tested by nested polymerase chain reaction in the serum and liver of 69 hepatitis B surface antigen (HBsAg) negative, anti-hepatitis C virus (HCV) positive patients (47 with HCV RNA and 22 without HCV RNA). Serum hepatitis B virus (HBV) DNA-was detected in 49% of the patients with HCV-RNA and in 64% of those without HCV-RNA. Furthermore, intrahepatic HBV-DNA was found in four of five (80%) of the biopsies analysed. Delta genome was found in 72% and 73%, respectively, of the anti-HCV positive patients with or without HCV-RNA. In addition, intrahepatic delta virus genome was detected in another four liver biopsies studied. In the group of patients with HCV-RNA, the simultaneous presence of hepatitis B and D genomes was statistically higher in transfused patients than in drug addicts, or in those with an unknown infection route (P < 0.001). These results show a high percentage of B and D genomes in HBsAg negative patients with anti-HCV, irrespective of the presence or absence of the HCV genome. However, the clinical implications of this finding should be examined in future studies. (C) 1995 Wiley-Liss, Inc.

引用

页码：168 / 173

页数：6

共 26 条

[1] DETECTION OF ANTIBODY TO HEPATITIS-C VIRUS IN PROSPECTIVELY FOLLOWED TRANSFUSION RECIPIENTS WITH ACUTE AND CHRONIC NON-A-HEPATITIS, NON-B-HEPATITIS [J].