THE FORMATION OF REACTIVE OXYGEN SPECIES IN A FRACTION OF RAT-BRAIN BY METABOLISM OF NITRIC-OXIDE

被引：17

作者：

BONDY, SC ^{[1
]}

NADERI, S ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,IRVINE OCCUPAT HLTH CTR,IRVINE,CA 92717

来源：

NEUROSCIENCE LETTERS | 1994年 / 168卷 / 1-2期

关键词：

NITRIC OXIDE; REACTIVE OXYGEN; FREE RADICAL; SUPEROXIDE; HYDROXYL RADICAL;

D O I：

10.1016/0304-3940(94)90409-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The potential of nitric oxide for the induction of reactive oxygen species (ROS) has been evaluated in a cerebral synaptosomal fraction. Nitric oxide (NO) was generated using S-nitroso-N-acetylpenicillamine (SNAP). NO stimulated ROS production, assayed using a fluorescent probe. This stimulation was largely inhibited by superoxide dismutase but not by catalase, implying that superoxide anion but not hydrogen peroxide, was a critical intermediate. An iron chelator, deferoxamine or hydroxyl radical scavengers failed to prevent stimulation of ROS by SNAP. This suggests the possibility of formation of a novel class of short-lived active oxygen species by NO.

引用

页码：34 / 36

页数：3

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